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1; Resident Evil 2
2; Final Fantasy X
4; The Legend of Zelda: Twilight Princess
5; Resident Evil 4/Code:Veronica
Resident Evil 2; This has been, and probably always will be, my favorite Resident Evil game. It's not as scary as it used to be to me, what with the old graphics and sometimes hilarious voice acting, but things still manage to jump me, even though I know the game by heart. The story also remains very important and interesting to me, all these years and sequels later.
Final Fantasy X; This game has been my favorite Final Fantasy since I played it, which is sad since IX used to hold that spot, but X just had so many elements that I was completely drawn to. The beautiful world plagued by "sin" the religious references, the diverse cast of characters, and the story was just so heartbreaking. I loved it, and I still can't listen to the music that plays during the ending without crying.
Okami; Granted I still haven't finished this game, but I think that it took a kind of overused story and added an amazingly fresh twist to it. It's a blast to "draw" on things, and the wolf is surprisingly capable in battle, which I loved. Not to mention the game itself is absolutely breathtaking in scenery and effect.
The Legend of Zelda: Twilight Princess; Yes, all of the Zelda games are the same thing, over and over, but I felt like TP added enough fresh new elements to really sort of give a new breath to the series. Midna for one thing, was an incredible touch, and the graphics were quite beautiful. The wolf link thing was also new, and the much more interactive horseback, as well as more three-dimensional backdrop characters.
Resident Evil 4/Code:Veronica; These two games tie for me, because they're both sequels for my favorite characters, and they're both such good games. Granted, 4 IS a little bit better than CV, but not enough to matter in my book. The stories are both important, in some way, and while not completely connected, it's still my Resident Evil love. Claire is finally reunited with her brother in CV, Leon has it confirmed for him that Ada is in fact alive. There's also annoying helper characters that you have to play as at some point. Although Steve is vastly more useful than Ashley. Because he has guns.